Laser-assisted Bioprinting

The Novalase laser bioprinter is a prototype developed in 2007 by an Inserm researcher in cooperation with the Novalase startup.

 

Main specificities :

 

  • Operating at kHz range: more than 1000 droplets printed per seconds.
  • Size of the printed droplets: 50µm to 300µm.
  • Printing from top to bottom.
  • Integrated video system to allow the positioning of the samples.

 

 

Microextrusion and Inkjet bioprinting

The 3D Discovery multimodal printer is a commercial bioprinter of RegenHU, comprising both microvalve and extrusion technologies.

Main specificities :

 

For microextrusion, the resolution is about 150 µm and 50 µm for microvalve bioprinting. 

Novalase Platform

Modulab Platform

3D Discovery platform (RegenHU) 

Bioink development

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The MODULAB printer is a prototype developed by the ALPhANOV laser center in collaboration with Inserm U1026.

 

Main specificities :

 

  • High accuracy printing in final pointing position
  • Tunable from single cell to a few tens of cell/droplets.
  • Integrated in a biosafety cabinet.
  • Printing directly on well plates. 

This equipment is in particular interesting for in-vitro studies.

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We have been developing biomaterial ink formulations that can specifically adapt to specified bioprinting procedures or that show better performances when using certain cell types or coculture systems.

 

We have mainly focused on the use of polymers/composites obtained from the extracellular matrix, as for the majority of the applications they have shown superior performances.

Also, due to inherent limitations/specifications of each bioprinting technology, we adapt the respective formulations to attain optimal printability, while respecting the specific requirements of each cell type.

 

In this process, we can assist you on the best formulation for your specific application, allow you to test several bioink formulations or develop (from scratch) a new biomaterial that suits your purpose.

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The overall performance of this platform is especially attractive for in vivo and in situ bioprinting, at this stage already tested and validated in mice animal models for bone tissue regeneration (Keriquel et al., 2017) and for the support of vasculogenesis (Kérourédan et al., 2019).

 

 

 

 

Figure selected from (Keriquel et al., 2017).

Biomaterial inks

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